共 21 条
[21]
WAJCHENBERG BL, 1964, DIABETES, V13, P170
EFFECT OF ADRENALECTOMY AND GLUCOCORTICOID TREATMENT ON THE LEVELS OF AN INSULIN-SENSITIVE GLYCOSYL-PHOSPHATIDYLINOSITOL IN ISOLATED RAT HEPATOCYTES
被引：9
作者：
CABELLO, MA
SANCHEZARIAS, JA
LIRAS, A
MATO, JM
FELIU, JE
机构：
[1] UNIV AUTONOMA MADRID,HOSP PUERTA HIERRO,SERV ENDOCRINOL EXPTL,SAN MARTIN PORRES 4,E-28035 MADRID,SPAIN
[2] CSIC,INST INVEST BIOMED,FDN JIMENEZ DIAZ,E-28040 MADRID,SPAIN
关键词：
(Rat hepatocytes);
Adrenalectomy;
Glucocorticoid;
Glycosyl-phosphatidylinositol;
Insulin resistance;
D O I：
10.1016/0303-7207(90)90173-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ;
090102 ;
摘要：
Insulin resistance caused by dexamethasone administration to rats was accompanied by a marked decrease in the hepatocyte content of an insulin-sensitive glycosyl-phosphatidylinositol, as well as by a blockade of its hydrolysis in response to this hormone. In contrast, bilateral adrenalectomy provoked a significant increase of the cellular glycosyl-phosphatidylinositol levels. Under all the assayed metabolic conditions, a close direct correlation was established between the basal content of this compound and the number of insulin receptors present in the isolated hepatocytes. © 1990.
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页码：R1 / R5
页数：5
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