DIRECT-DETECTION OF INFECTIOUS HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) IMMUNE-COMPLEXES IN THE SERA OF HIV-1-INFECTED PERSONS

被引:9
作者
KOBAYASHI, K
TAKEDA, A
GREEN, S
TUAZON, CU
ENNIS, FA
机构
[1] UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV INFECT DIS & IMMUNOL,55 LAKE AVE N,WORCESTER,MA 01655
[2] GEORGE WASHINGTON UNIV,SCH MED,DEPT MED,WASHINGTON,DC 20052
关键词
D O I
10.1093/infdis/168.3.729
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The sera of human immunodeficiency virus type 1 (HIV-1)-infected subjects were examined for the presence of infectious HIV-1-antibody complexes by their ability to infect Fcgamma receptor (FcgammaR)-bearing cells. Infection of FcgammaR-bearing cells by a serum in which half of the p24 antigen was present in a form of immune complexes was inhibited by aggregated human immunoglobulin. Then in studies on 22 sera, 9 sera produced p24 antigen during 14 days of culture in U937 cells. HIV-1 p24 production was inhibited or delayed by the pretreatment of cells with aggregated human immunoglobulin in 6 of the 9 sera that were infectious. These results may reflect interactions between virus-antibody complexes and FcgammaR-bearing cells in vivo because serum itself was used as the source of virus and virus-antibody complexes. The results indicate that infectious HIV-1 immune complexes are present in the circulation of HIV-1-infected patients.
引用
收藏
页码:729 / 732
页数:4
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