ANALYSIS OF SPERM CHROMOSOME COMPLEMENTS FROM A MAN HETEROZYGOUS FOR A PERICENTRIC-INVERSION, INV(8)(P23Q22)

被引：21

作者：

MARTIN, RH ^{[1
]}

机构：

[1] UNIV CALGARY,FAC MED,DEPT PEDIAT,DIV MED GENET,CALGARY T2N 1N4,ALBERTA,CANADA

来源：

CYTOGENETICS AND CELL GENETICS | 1993年 / 62卷 / 04期

关键词：

D O I：

10.1159/000133475

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human sperm chromosomes were studied in a man heterozygous for a pericentric inversion (p23q22) of chromosome 8. The pronuclear chromosomes were analyzed after in vitro penetration of golden hamster eggs. A total of 166 sperm were examined; 88.6% were chromosomally balanced and 11.4% were recombinant. Of the balanced complements, the proportion with a normal chromosome 8 (53.6%) was approximately equal to the proportion with an inverted 8 (46.4%). Of the recombinant complements, the proportion of sperm with a duplication of 8q and a deletion of 8p (5.7%) was equal to the reciprocal event of a duplication of 8p and a deletion of 8q (5.7%). The frequencies of X-bearing (53.2%) and Y-bearing sperm (46.8%) were not significantly different from the expected 1:1 ratio. There was no evidence for an interchromosomal effect. A total of four pericentric inversions have been studied by human sperm chromosome analysis; recombinant chromosomes have been observed in two of the four cases.

引用

页码：199 / 202

页数：4

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