RING ENLARGEMENT BY ALKYLATED 3-HYDROXYBUTYRATES - A SYNTHESIS OF (12S, 13R)-(-)-12-METHYL-13-TETRADECANOLIDE

被引：20

作者：

KRAFT, P ^{[1
]}

TOCHTERMANN, W ^{[1
]}

机构：

[1] CHRISTIAN ALBRECHTS UNIV KIEL,INST ORGAN CHEM,D-24098 KIEL,GERMANY

来源：

TETRAHEDRON | 1995年 / 51卷 / 40期

关键词：

FRATER ALKYLATION; MACROLIDES; RING ENLARGEMENT; ODOR AND STRUCTURE; CIRCULAR DICHROISM;

D O I：

10.1016/0040-4020(95)00664-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

TBS-protected iodo alkohols 6 were prepared via Frater alkylation and applied in the synthesis of optically active macrolides 5 and 10. By ring enlargement of cyclodecanone (7) the superposition molecule 5 of two macrocyclic odorants was synthesized and a conformationally fixed tricyclic macrolide 11 constructed.

引用

页码：10875 / 10882

页数：8

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