REGULATION OF MELANOMA BY THE EMBRYONIC SKIN

被引：74

作者：

GERSCHENSON, M ^{[1
]}

GRAVES, K ^{[1
]}

CARSON, SD ^{[1
]}

WELLS, RS ^{[1
]}

PIERCE, GB ^{[1
]}

机构：

[1] UNIV COLORADO, HLTH SCI CTR, SCH MED, DEPT PATHOL, DENVER, CO 80262 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1986年 / 83卷 / 19期

关键词：

D O I：

10.1073/pnas.83.19.7307

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This report focuses on the regulation of murine melanoma by the embryonic skin. A surgical technique was developed to allow injection of B16 melanoma cells into the embryo in utero. A significant decrease in incidence of tumors was noted, which correlated with the time of arrival of normally migrating premelanocytes into the skin. Media were conditioned from skin explanted at the time premelanocytes arrive in it; these media inhibited the growth of melanoma cells in vitro. Under optimal conditions the growth of melanoma cells ceased; the cells had altered morphology and failed to proliferate when placed in fresh growth media.

引用

页码：7307 / 7310

页数：4