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SPECIFIC BINDING OF HUMAN INTERLEUKIN-3 AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR TO HUMAN BASOPHILS
被引:34
作者
:
LOPEZ, AF
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,SEATTLE,WA
LOPEZ, AF
LYONS, AB
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,SEATTLE,WA
LYONS, AB
EGLINTON, JM
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,SEATTLE,WA
EGLINTON, JM
PARK, LS
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,SEATTLE,WA
PARK, LS
TO, LB
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,SEATTLE,WA
TO, LB
CLARK, SC
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,SEATTLE,WA
CLARK, SC
VADAS, MA
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,SEATTLE,WA
VADAS, MA
机构
:
[1]
IMMUNEX CORP,SEATTLE,WA
[2]
GENET INST,CAMBRIDGE,MA
来源
:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
|
1990年
/ 85卷
/ 01期
基金
:
英国医学研究理事会;
关键词
:
D O I
:
10.1016/0091-6749(90)90229-W
中图分类号
:
R392 [医学免疫学];
学科分类号
:
100102 ;
摘要
:
The human T cell-derived cytokines interleukin (IL)-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF) were examined for their ability to bind to human basophils. Basophils were obtained from the peripheral blood of a patient with chronic myeloid leukemia undergoing basophilic differentiation after purification on a density gradient of metrizamide. Binding studies with 125I-labeled IL-3 and 125I-labeled GM-CSF demonstrated that basophils express a single class of high-affinity receptors for each of these molecules. Saturation binding curves with 125I-labeled IL-3 revealed that IL-3 bound specifically to basophils, and analysis according to the method of Scatchard revealed that basophils express 800 to 900 receptors per cell with an apparent dissociation constant of 2.6 × 10-11 mol/L. Saturation-binding curves with 125I-labeled GM-CSF revealed that basophils express 100 to 200 receptors per cell with an apparent dissociation constant of 4 × 10-11 mol/L. The demonstration of high-affinity receptors for IL-3 and GM-CSF on human basophils suggests a role for these cytokines in the regulation of basophil function. © 1990.
引用
收藏
页码:99 / 102
页数:4
相关论文
共 29 条
[21]
CHARACTERIZATION OF THE CELL-SURFACE RECEPTOR FOR HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR
PARK, LS
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
PARK, LS
FRIEND, D
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
FRIEND, D
GILLIS, S
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
GILLIS, S
URDAL, DL
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
URDAL, DL
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
1986,
164
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: 251
-
262
[22]
PARK LS, 1989, J BIOL CHEM, V264, P5420
[23]
SELECTIVE DIFFERENTIATION AND PROLIFERATION OF HEMATOPOIETIC-CELLS INDUCED BY RECOMBINANT HUMAN INTERLEUKINS
SAITO, H
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
SAITO, H
HATAKE, K
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
HATAKE, K
DVORAK, AM
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
DVORAK, AM
LEIFERMAN, KM
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
LEIFERMAN, KM
DONNENBERG, AD
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
DONNENBERG, AD
ARAI, N
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
ARAI, N
ISHIZAKA, K
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
ISHIZAKA, K
ISHIZAKA, T
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
ISHIZAKA, T
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
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THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
SCATCHARD, G
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0
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0
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0
SCATCHARD, G
[J].
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,
1949,
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[25]
CURRENT CONCEPTS - MEDIATORS OF IMMEDIATE HYPERSENSITIVITY REACTIONS
SERAFIN, WE
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115
SERAFIN, WE
AUSTEN, KF
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115
AUSTEN, KF
[J].
NEW ENGLAND JOURNAL OF MEDICINE,
1987,
317
(01)
: 30
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34
[26]
INTERFERON-GAMMA AND B-CELL STIMULATORY FACTOR-I RECIPROCALLY REGULATE IG ISOTYPE PRODUCTION
SNAPPER, CM
论文数:
0
引用数:
0
h-index:
0
SNAPPER, CM
PAUL, WE
论文数:
0
引用数:
0
h-index:
0
PAUL, WE
[J].
SCIENCE,
1987,
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[27]
VADAS MA, 1983, J IMMUNOL, V130, P795
[28]
VADAS MA, 1979, J IMMUNOL, V122, P1228
[29]
YANG YC, 1988, BLOOD, V71, P958
←
1
2
3
→
共 29 条
[21]
CHARACTERIZATION OF THE CELL-SURFACE RECEPTOR FOR HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR
PARK, LS
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
PARK, LS
FRIEND, D
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
FRIEND, D
GILLIS, S
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
GILLIS, S
URDAL, DL
论文数:
0
引用数:
0
h-index:
0
机构:
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
IMMUNEX CORP,51 UNIV ST,SEATTLE,WA 98101
URDAL, DL
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
1986,
164
(01)
: 251
-
262
[22]
PARK LS, 1989, J BIOL CHEM, V264, P5420
[23]
SELECTIVE DIFFERENTIATION AND PROLIFERATION OF HEMATOPOIETIC-CELLS INDUCED BY RECOMBINANT HUMAN INTERLEUKINS
SAITO, H
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
SAITO, H
HATAKE, K
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
HATAKE, K
DVORAK, AM
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
DVORAK, AM
LEIFERMAN, KM
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
LEIFERMAN, KM
DONNENBERG, AD
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
DONNENBERG, AD
ARAI, N
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
ARAI, N
ISHIZAKA, K
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
ISHIZAKA, K
ISHIZAKA, T
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
ISHIZAKA, T
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
85
(07)
: 2288
-
2292
[24]
THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
SCATCHARD, G
论文数:
0
引用数:
0
h-index:
0
SCATCHARD, G
[J].
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,
1949,
51
(04)
: 660
-
672
[25]
CURRENT CONCEPTS - MEDIATORS OF IMMEDIATE HYPERSENSITIVITY REACTIONS
SERAFIN, WE
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115
SERAFIN, WE
AUSTEN, KF
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115
AUSTEN, KF
[J].
NEW ENGLAND JOURNAL OF MEDICINE,
1987,
317
(01)
: 30
-
34
[26]
INTERFERON-GAMMA AND B-CELL STIMULATORY FACTOR-I RECIPROCALLY REGULATE IG ISOTYPE PRODUCTION
SNAPPER, CM
论文数:
0
引用数:
0
h-index:
0
SNAPPER, CM
PAUL, WE
论文数:
0
引用数:
0
h-index:
0
PAUL, WE
[J].
SCIENCE,
1987,
236
(4804)
: 944
-
947
[27]
VADAS MA, 1983, J IMMUNOL, V130, P795
[28]
VADAS MA, 1979, J IMMUNOL, V122, P1228
[29]
YANG YC, 1988, BLOOD, V71, P958
←
1
2
3
→