INTRAMOLECULAR CYCLOADDITION REACTIONS OF DIENYL NITROSO-COMPOUNDS - APPLICATION TO THE SYNTHESIS OF MITOMYCIN-K

被引:52
作者
BENBOW, JW [1 ]
MCCLURE, KF [1 ]
DANISHEFSKY, SJ [1 ]
机构
[1] YALE UNIV,DEPT CHEM,NEW HAVEN,CT 06511
关键词
D O I
10.1021/ja00079a010
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The total synthesis of mitomycin K has been achieved. The key reaction produced pyrrolo[1,2-a]indole 25 from dienyl nitrobenzenemethanol 23 by a process involving two internal photochemical redox transformations and a [4 + 2] cycloaddition.
引用
收藏
页码:12305 / 12314
页数:10
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