ANTI-ASIALO-GM1 INHIBITS VACCINIA VIRUS-INFECTION OF MURINE OVARIES - ASIALO-GM1 AS AN ADDITIONAL VIRUS RECEPTOR

被引：13

作者：

KARUPIAH, G ^{[1
]}

BLANDEN, RV ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV CELL BIOL,POB 334,CANBERRA,ACT 2601,AUSTRALIA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 1990年 / 68卷

关键词：

D O I：

10.1038/icb.1990.46

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The neurovirulent strain of vaccinia virus, VV-WR, or recombinants derived from VV-WR, cause highly productive infection of murine ovaries, but infection could be partially inhibited in vivo using an antiserum to asialo-GM1 (as-GM1). In vitro analysis by flow cytometry revealed that murine ovarian cells expressed a cell surface antigen identical to or cross-reactive with as-GM1. The capacity of VV-WR to infect murine ovaries appears to depend in part upon as-GM1 expression on ovarian cells.

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页码：343 / 346

页数：4

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