THE OXYGEN-SUPPLY DEPENDENCY PHENOMENON IS ASSOCIATED WITH INCREASED BLOOD LACTATE LEVELS

[71] Crie, Wildenthal, Adcock, Et al., Inhibition of inotropic effect of hyperosmotic mannitol by lactate in vitro, Am J Physiol, 231, pp. 1209-1213, (1976)

[72] Cain, Adams, O₂ transport during two forms of stagnant hypoxia following acid and base infusions, J Appl Physiol, 54, pp. 1518-1524, (1983)

[73] Gores, Nieminen, Wray, Et al., Intracellular pH during “chemical hypoxia” in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death, J Clin Invest, 83, pp. 386-396, (1989)

[74] Graf, Leach, Arieff, Evidence for a detrimental effect of bicarbonate therapy in hypoxic lactic acidosis, Science, 227, pp. 754-756, (1985)

[75] Bersin, Arieff, Improved hemodynamic function during hypoxia with carbicarb, a new agent for the management of acidosis, Circulation, 77, pp. 227-233, (1988)

[76] Sun, Filley, Hord, Et al., Carbicarb: An effective substitute for NaHCO3 for the treatment of acidosis, Surgery, 102, pp. 835-839, (1987)

[77] Kette, Weil, Von Planta, Et al., Buffer agents do not reverse intramyocardial acidosis during cardiac resuscitation, Circulation, 81, pp. 1660-1666, (1990)

[78] Klepper, Kucera, Kindig, Et al., A comparative study of sodium bicarbonate and carbicarb in the treatment of metabolic acidosis induced by hemorrhagic shock, Journal of Critical Care, 4, pp. 256-261, (1988)

[79] Blecic, De Backer, Deleuze, Et al., Correction of metabolic acidosis in experimental CPR: A comparative study of sodium bicarbonate, carbicarb and dextrose, Ann Emerg Med, 20, pp. 235-238, (1991)

[80] Crabb, Yount, Harris, The metabolic effects of dichloroacetate in dogs, Metabolism, 30, pp. 1024-1039, (1981)

[71] Crie, Wildenthal, Adcock, Et al., Inhibition of inotropic effect of hyperosmotic mannitol by lactate in vitro, Am J Physiol, 231, pp. 1209-1213, (1976)

[72] Cain, Adams, O₂ transport during two forms of stagnant hypoxia following acid and base infusions, J Appl Physiol, 54, pp. 1518-1524, (1983)

[73] Gores, Nieminen, Wray, Et al., Intracellular pH during “chemical hypoxia” in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death, J Clin Invest, 83, pp. 386-396, (1989)

[74] Graf, Leach, Arieff, Evidence for a detrimental effect of bicarbonate therapy in hypoxic lactic acidosis, Science, 227, pp. 754-756, (1985)

[75] Bersin, Arieff, Improved hemodynamic function during hypoxia with carbicarb, a new agent for the management of acidosis, Circulation, 77, pp. 227-233, (1988)

[76] Sun, Filley, Hord, Et al., Carbicarb: An effective substitute for NaHCO3 for the treatment of acidosis, Surgery, 102, pp. 835-839, (1987)

[77] Kette, Weil, Von Planta, Et al., Buffer agents do not reverse intramyocardial acidosis during cardiac resuscitation, Circulation, 81, pp. 1660-1666, (1990)

[78] Klepper, Kucera, Kindig, Et al., A comparative study of sodium bicarbonate and carbicarb in the treatment of metabolic acidosis induced by hemorrhagic shock, Journal of Critical Care, 4, pp. 256-261, (1988)

[79] Blecic, De Backer, Deleuze, Et al., Correction of metabolic acidosis in experimental CPR: A comparative study of sodium bicarbonate, carbicarb and dextrose, Ann Emerg Med, 20, pp. 235-238, (1991)

[80] Crabb, Yount, Harris, The metabolic effects of dichloroacetate in dogs, Metabolism, 30, pp. 1024-1039, (1981)