PROFOUND IMMUNOLOGICAL-TOLERANCE IN THE ANTIBODY-RESPONSE AGAINST BOVINE ALPHA(S1)-CASEIN INDUCED BY INTRADERMAL ADMINISTRATION OF A DOMINANT T-CELL DETERMINANT

被引:8
作者
HIRAHARA, K [1 ]
HISATSUNE, T [1 ]
CHOI, CY [1 ]
KAMINOGAWA, S [1 ]
机构
[1] UNIV TOKYO,DEPT APPL BIOL CHEM,BUNKYO KU,TOKYO 113,JAPAN
来源
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1995年 / 76卷 / 01期
关键词
D O I
10.1006/clin.1995.1082
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunological tolerance induced by intradermal administration of a peptide from a major milk protein antigen, alpha(s1)-casein, was investigated. When the peptide corresponding to amino acid residues 91-110 of alpha(s1)-casein, which included the dominant T cell determinant, was administered intradermally to mice which were subsequently immunized with alpha(s1)-casein, immunological tolerance in T cell response against alpha(s1)-casein was induced. Furthermore, intradermal administration of P91-110 induced profound immunological tolerance in the antibody response against native whole protein alpha(s1)-casein. The anti-alpha(s1)-casein antibody responses of IgG2a and IgG2b (the subclasses induced by Th1) and of IgG1 (the subclass induced by Th2) were all greatly suppressed by injecting P91-110 or alpha(s1)-casein. Our study is the first to demonstrate that intradermal administration of a dominant T cell determinant induces profound immunological tolerance in the antibody response against the native protein antigen. (C) 1995 Academic Press, Inc.
引用
收藏
页码:12 / 18
页数:7
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