PROFOUND IMMUNOLOGICAL-TOLERANCE IN THE ANTIBODY-RESPONSE AGAINST BOVINE ALPHA(S1)-CASEIN INDUCED BY INTRADERMAL ADMINISTRATION OF A DOMINANT T-CELL DETERMINANT

被引：8

作者：

HIRAHARA, K ^{[1
]}

HISATSUNE, T ^{[1
]}

CHOI, CY ^{[1
]}

KAMINOGAWA, S ^{[1
]}

机构：

[1] UNIV TOKYO,DEPT APPL BIOL CHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1995年 / 76卷 / 01期

关键词：

D O I：

10.1006/clin.1995.1082

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunological tolerance induced by intradermal administration of a peptide from a major milk protein antigen, alpha(s1)-casein, was investigated. When the peptide corresponding to amino acid residues 91-110 of alpha(s1)-casein, which included the dominant T cell determinant, was administered intradermally to mice which were subsequently immunized with alpha(s1)-casein, immunological tolerance in T cell response against alpha(s1)-casein was induced. Furthermore, intradermal administration of P91-110 induced profound immunological tolerance in the antibody response against native whole protein alpha(s1)-casein. The anti-alpha(s1)-casein antibody responses of IgG2a and IgG2b (the subclasses induced by Th1) and of IgG1 (the subclass induced by Th2) were all greatly suppressed by injecting P91-110 or alpha(s1)-casein. Our study is the first to demonstrate that intradermal administration of a dominant T cell determinant induces profound immunological tolerance in the antibody response against the native protein antigen. (C) 1995 Academic Press, Inc.

引用

页码：12 / 18

页数：7

共 40 条

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