Regulation of energy metabolism in liver

被引：45

作者：

Soboll, S

机构：

[1] Institut für Physiologische Chemie I, Heinrich Heine-Universität Düsseldorf, Düsseldorf, 40225

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1995年 / 27卷 / 06期

关键词：

energy metabolism; liver mitochondria; metabolic control; nonequilibrium thermodynamics;

D O I：

10.1007/BF02111655

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Energy metabolism in liver has to cope with the special tasks of this organ in intermediary metabolism. Main ATP-generating processes in the liver cell are the respiratory chain and glycolysis, whereas main ATP-consuming processes are gluconeogenesis, urea synthesis, protein synthesis, ATPases and mitochondrial proton leak. Mitochondrial respiratory chain in the intact liver cell is subject to control mainly by substrate (hydrogen donors, ADP, oxygen) transport and supply and proton leak/slip. Whereas hormonal control is mainly on substrate supply to mitochondria, proton leak/slip is supposed to play an important role in the modulation of the efficiency of oxidative phosphorylation.

引用

页码：571 / 582

页数：12

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