PHARMACOKINETICS OF QUININE AND DOXYCYCLINE IN PATIENTS WITH ACUTE FALCIPARUM-MALARIA - A STUDY IN AFRICA

被引：12

作者：

COUET, W

LAROCHE, R

FLOCH, JJ

ISTIN, B

FOURTILLAN, JB

SAUNIERE, JF

机构：

[1] INSEAD,FONTAINEBLEAU,FRANCE

[2] CHU KAMENGUE,MALAD INFECT SERV,BUJUMBURA,BURUNDI

[3] CHU KAMENGUE,BIOCHIM LAB,BUJUMBURA,BURUNDI

来源：

THERAPEUTIC DRUG MONITORING | 1991年 / 13卷 / 06期

关键词：

ACUTE FALCIPARUM MALARIA; QUININE; DOXYCYCLINE; PHARMACOKINETICS;

D O I：

10.1097/00007691-199111000-00005

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The pharmacokinetics of quinine was investigated in patients with acute falciparum malaria treated with quinine alone or in the presence of doxycycline. Twenty-six patients divided into two groups of equal number were enrolled in the study. In the absence of doxycycline, the volume of distribution of quinine (mean +/- SD) was estimated to be 1.32 +/- 0.32 L/kg, and its clearance was 0.125 +/- 0.47 L/h/kg, which was only in partial agreement with previously published data. No effect of doxycycline on the pharmacokinetics of quinine was observed.

引用

页码：496 / 501

页数：6

共 23 条

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