SPECTROPHOTOMETRIC DETERMINATION OF ISONIAZID USING ETHYL 8-QUINOLINOXY ACETATE

被引：19

作者：

AHMED, AHN ^{[1
]}

ELGIZAWY, SM ^{[1
]}

ELSUBBAGH, HI ^{[1
]}

机构：

[1] MANSOURA UNIV,FAC PHARM,DEPT MED CHEM,MANSOURA,EGYPT

来源：

ANALYTICAL LETTERS | 1992年 / 25卷 / 01期

关键词：

SPECTROPHOTOMETRY; ISONIAZID ASSAY; SYNTHESIS; ETHYL 8-QUINOLINOXY ACETATE; HYDRAZIDE;

D O I：

10.1080/00032719208020009

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A colorimetric method based on the interaction of isonlazid and the newly synthesized ethyl 8-quinolinoxy acetate (2) was developed. The absorbance was measured at 504 nm and the procedure was found to be sensitive for INH in the 10(-4) M range. The method was applied to the analysis of the drug in pharmaceutical dosage forms and proved to be simple, demonstrating good accuracy and precision. Structural elucidation of the reagent 2 as well as the chromogen 4 has been achieved using H-1 NMR and elemental analyses.

引用

页码：73 / 80

页数：8

共 16 条

[1]

ABDULLA MA, 1990, AM ASS PHARM SCI

[2]

FILIPEVA S A, 1989, Farmatsiya (Moscow), V38, P67

[3] CONTINUOUS-FLOW CHEMILUMINESCENCE DETERMINATION OF ISONIAZID BY OXIDATION WITH N-BROMOSUCCINIMIDE [J].