CONTRALATERAL EARLY BLINK REFLEX IN PATIENTS WITH HTLV-I-ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS

被引:17
作者
LEONS, FE [1 ]
ARIMURA, K [1 ]
ARIMURA, Y [1 ]
SONODA, Y [1 ]
OSAME, M [1 ]
机构
[1] KAGOSHIMA UNIV,SCH MED,DEPT PHYSIOL 2,KAGOSHIMA 890,JAPAN
关键词
HAM/TSP; BLINK REFLEX; CROSSED R1; FACIAL NUCLEUS; INTERNEURONAL NETWORK;
D O I
10.1016/0022-510X(94)00205-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Thirty-two Japanese patients with HTLV-I-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) were studied by means of the electrically elicited blink reflex and three responses (R1, R2, R3) were registered. 69% of the patients displayed a uni- or bilateral crossed R1 response (R1k) as compared to 11% in the control group. A positive correlation between R1k and an exaggerated jaw jerk reflex was found in the patients. Central abnormalities of the nervous system with diminished presynaptic inhibition acting in the interneuronal input of the brainstem of HAM/TSP patients was the most likely cause. It could lead to the unmasking of crossed trigemino-facial pathway reflex which is present in the normal population from birth. These results strongly support the supraspinal involvement of the central nervous system (CNS) in HAM/TSP more than usually thought.
引用
收藏
页码:51 / 57
页数:7
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