FORMATION OF PYRROLE DERIVATIVES FROM HETEROATOM-SUBSTITUTED ACETONITRILES

被引：4

作者：

JENG, HJ ^{[1
]}

FANG, JM ^{[1
]}

机构：

[1] NATL TAIWAN UNIV,DEPT CHEM,TAIPEI 106,TAIWAN

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 1994年 / 41卷 / 06期

关键词：

AMINOMALONONITRILE; 2-CHLORO-2-PHENYLTHIOACETONITRILE; 1-PHENYLTHIOCYCLOPROPANECARBONITRILE; 3H-PYRROLINE; PYRROLE;

D O I：

10.1002/jccs.199400112

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aminomalononitrile reacted with conjugated carbonyl compounds to give H-3-pyrrolines. Treatment of 2-chloro-2-phenylthioacetonitrile with alkenes in the presence of potassium t-butoxide afforded 1-phenyIthiocyclopropanecarbonitriles, which reacted with nucleophiles in 1,2-, 1,4- or 1,6-addition modes. The 1,2-adducts (cyclopropylimines) rearranged in situ to give substituted pyrroles.

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页码：803 / 811

页数：9

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