Nature and Nurture of Human Pain

被引：30

作者：

Belfer, Inna ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Dept Anesthesiol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15213 USA

来源：

SCIENTIFICA | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/415279

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Humans are very different when it comes to pain. Some get painful piercings and tattoos; others can not stand even a flu shot. Interindividual variability is one of the main characteristics of human pain on every level including the processing of nociceptive impulses at the periphery, modification of pain signal in the central nervous system, perception of pain, and response to analgesic strategies. As for many other complex behaviors, the sources of this variability come from both nurture (environment) and nature (genes). Here, I will discuss howthese factors contribute to human pain separately and via interplay and howepigenetic mechanisms add to the complexity of their effects.

引用

页数：19

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