A NEW MULTIENZYME SYSTEM FOR A ONE-POT SYNTHESIS OF SIALYL OLIGOSACCHARIDES - COMBINED USE OF BETA-GALACTOSIDASE AND ALPHA(2,6)-SIALYLTRANSFERASE COUPLED WITH REGENERATION INSITU OF CMP-SIALIC ACID

被引：59

作者：

HERRMANN, GF

ICHIKAWA, Y

WANDREY, C

GAETA, FCA

PAULSON, JC

WONG, CH

机构：

[1] Scripps Res Inst, DEPT CHEM, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA

[2] RES CTR JULICH, INST BIOTECHNOL, W-5170 JULICH, GERMANY

[3] CYTEL CORP, SAN DIEGO, CA 92121 USA

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)93387-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An irreversible one-pot enzymatic synthesis of sialyl oligosaccharides has been achieved with a beta-galactosidase-catalyzed galactosylation of an acceptor followed by a sialyltransferase-catalyzed sialylation with regeneration in situ of CMP-sialic acid.

引用

页码：3091 / 3094

页数：4

共 24 条

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