PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF THE 5HT3 RECEPTOR, A SEROTONIN-GATED ION CHANNEL

被引:884
作者
MARICQ, AV
PETERSON, AS
BRAKE, AJ
MYERS, RM
JULIUS, D
机构
[1] UNIV CALIF SAN FRANCISCO, DEPT PHARMACOL, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA
[3] UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA
关键词
D O I
10.1126/science.1718042
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The neurotransmitter serotonin (5HT) activates a variety of second messenger signaling systems and through them indirectly regulates the function of ion channels. Serotonin also activates ion channels directly, suggesting that it may also mediate rapid, excitatory responses. A complementary DNA clone containing the coding sequence of one of these rapidly responding channels, a 5HT3 subtype of the serotonin receptor, has been isolated by screening a neuroblastoma expression library for functional expression of serotonin-gated currents in Xenopus oocytes. The predicted protein product has many of the features shared by other members of the ligand-gated ion channel family. The pharmacological and electrophysiological characteristics of the cloned receptor are largely consistent with the properties of native 5HT3 receptors. Messenger RNA encoding this receptor is found in the brain, spinal cord, and heart. This receptor defines a new class of excitatory ligand-gated channels.
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页码:432 / 437
页数:6
相关论文
共 62 条
  • [51] DIVALENT-CATIONS MODULATE 5-HT3 RECEPTOR-INDUCED CURRENTS IN N1E-115 NEURO-BLASTOMA CELLS
    PETERS, JA
    HALES, TG
    LAMBERT, JJ
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 151 (03) : 491 - 495
  • [52] RAPPORT MM, 1948, J BIOL CHEM, V176, P1243
  • [53] THE PHARMACOLOGY AND FUNCTION OF 5-HT3 RECEPTORS
    RICHARDSON, BP
    ENGEL, G
    [J]. TRENDS IN NEUROSCIENCES, 1986, 9 (09) : 424 - 428
  • [54] IDENTIFICATION OF SEROTONIN M-RECEPTOR SUBTYPES AND THEIR SPECIFIC BLOCKADE BY A NEW CLASS OF DRUGS
    RICHARDSON, BP
    ENGEL, G
    DONATSCH, P
    STADLER, PA
    [J]. NATURE, 1985, 316 (6024) : 126 - 131
  • [55] Richardson BP, 1988, NEURONAL SEROTONIN, P465
  • [56] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS
    SANGER, F
    NICKLEN, S
    COULSON, AR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5463 - 5467
  • [57] FUNCTIONAL EXPRESSION IN XENOPUS OOCYTES OF THE STRYCHNINE BINDING 48 KD SUBUNIT OF THE GLYCINE RECEPTOR
    SCHMIEDEN, V
    GRENNINGLOH, G
    SCHOFIELD, PR
    BETZ, H
    [J]. EMBO JOURNAL, 1989, 8 (03) : 695 - 700
  • [58] SEQUENCE AND FUNCTIONAL EXPRESSION OF THE GABA-A RECEPTOR SHOWS A LIGAND-GATED RECEPTOR SUPER-FAMILY
    SCHOFIELD, PR
    DARLISON, MG
    FUJITA, N
    BURT, DR
    STEPHENSON, FA
    RODRIGUEZ, H
    RHEE, LM
    RAMACHANDRAN, J
    REALE, V
    GLENCORSE, TA
    SEEBURG, PH
    BARNARD, EA
    [J]. NATURE, 1987, 328 (6127) : 221 - 227
  • [59] DIFFERENTIATION OF NG108-15 CELLS ALTERS CHANNEL CONDUCTANCE AND DESENSITIZATION KINETICS OF THE 5-HT3 RECEPTOR
    SHAO, XM
    YAKEL, JL
    JACKSON, MB
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1991, 65 (03) : 630 - 638
  • [60] TUTTON PJM, 1987, ANTICANCER RES, V7, P1