ROLES OF IRON IN NEOPLASIA - PROMOTION, PREVENTION, AND THERAPY

被引:52
作者
WEINBERG, ED [1 ]
机构
[1] INDIANA UNIV, PROGRAM MED SCI, BLOOMINGTON, IN 47405 USA
关键词
IRON; ROLES IN NEOPLASIA; NEOPLASIA; ROLES OF IRON IN; CANCER PREVENTION AND THERAPY;
D O I
10.1007/BF02785242
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Research and clinical observations during the past six decades have shown that: 1. Iron promotes cancer cell growth; 2. Hosts attempt to withhold or withdraw iron from cancer cells; and 3. Iron is a factor in prevention and in therapy of neoplastic disease. Although normal and neoplastic cells have similar qualitative requirements for iron, the neoplastic cells have more flexibility in acquisition of the metal. Excessive iron levels in animals and humans are associated with enhanced neoplastic cell growth. In invaded hosts, cytokine-activated macrophages increase intracellular ferritin retention of the metal, scavenge iron in areas of tumor growth, and secrete reactive nitrogen intermediates to effect efflux of nonheme iron from tumor cells. Procedures associated with lowering host intake of excess iron can assist in prevention and in management of neoplastic disease. Chemical methods for prevention of iron assimilation by neoplastic cells are being developed in experimental and clinical protocols. The antineoplastic activity of a considerable variety of chemicals, as well as of radiation, is modulated by iron. The present article focuses on recent findings and suggests directions for further cancer-iron research.
引用
收藏
页码:123 / 140
页数:18
相关论文
共 118 条
[41]  
2-F
[42]  
FAULK WP, 1980, LANCET, V2, P390
[43]   TRANSFERRIN RECEPTORS IN HUMAN-TISSUES - THEIR DISTRIBUTION AND POSSIBLE CLINICAL RELEVANCE [J].
GATTER, KC ;
BROWN, G ;
TROWBRIDGE, IS ;
WOOLSTON, RE ;
MASON, DY .
JOURNAL OF CLINICAL PATHOLOGY, 1983, 36 (05) :539-545
[44]   ANTIOXIDANT FUNCTIONS OF PHYTIC ACID [J].
GRAF, E ;
EATON, JW .
FREE RADICAL BIOLOGY AND MEDICINE, 1990, 8 (01) :61-69
[45]  
GRAF E, 1985, CANCER-AM CANCER SOC, V56, P717, DOI 10.1002/1097-0142(19850815)56:4<717::AID-CNCR2820560402>3.0.CO
[46]  
2-4
[47]   METABOLIC-FATE OF L-ARGININE IN RELATION TO MICROBIOSTATIC CAPABILITY OF MURINE MACROPHAGES [J].
GRANGER, DL ;
HIBBS, JB ;
PERFECT, JR ;
DURACK, DT .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (01) :264-273
[48]   SITES OF INHIBITION OF MITOCHONDRIAL ELECTRON-TRANSPORT IN MACROPHAGE-INJURED NEOPLASTIC-CELLS [J].
GRANGER, DL ;
LEHNINGER, AL .
JOURNAL OF CELL BIOLOGY, 1982, 95 (02) :527-535
[49]   IRON INHIBITS THE NONSPECIFIC TUMORICIDAL ACTIVITY OF MACROPHAGES - A POSSIBLE CONTRIBUTORY MECHANISM FOR NEOPLASIA IN HEMOCHROMATOSIS [J].
GREEN, R ;
ESPARZA, I ;
SCHREIBER, R .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1988, 526 :301-309
[50]  
HALLIWELL B, 1989, NEW ENGL J MED, V320, P399