PROTEIN MEASUREMENTS IN EARLY PRENATAL DIAGNOSIS OF SPINA-BIFIDA

被引：7

作者：

BROCK, DJH ^{[1
]}

机构：

[1] UNIV EDINBURGH, WESTERN GEN HOSP, DEPT HUMAN GENET, EDINBURGH EH4 2HU, SCOTLAND

来源：

HUMAN HEREDITY | 1976年 / 26卷 / 06期

关键词：

D O I：

10.1159/000152835

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Measurement of .beta.-lipoprotein concentration in amniotic fluid is introduced as a new parameter for the early prenatal diagnosis of spina bifida. It was successful in 15 cases of spina bifida, but failed in 5 cases of open spina bifida and 2 cases of closed spina bifida. All assays were performed before the end of the 2nd trimester and most between 15 and 20 wk of pregnancy. .beta.-Lipoprotein was compared with .alpha.-fetoprotein and .alpha.2-macroglobulin in its effectiveness in diagnosing spina bifida early enough to allow a termination of pregnancy.

引用

页码：401 / 408

页数：8

共 22 条

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[10]

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