PROTEIN MEASUREMENTS IN EARLY PRENATAL DIAGNOSIS OF SPINA-BIFIDA

被引：7

作者：

BROCK, DJH ^{[1
]}

机构：

[1] UNIV EDINBURGH, WESTERN GEN HOSP, DEPT HUMAN GENET, EDINBURGH EH4 2HU, SCOTLAND

来源：

HUMAN HEREDITY | 1976年 / 26卷 / 06期

关键词：

D O I：

10.1159/000152835

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Measurement of .beta.-lipoprotein concentration in amniotic fluid is introduced as a new parameter for the early prenatal diagnosis of spina bifida. It was successful in 15 cases of spina bifida, but failed in 5 cases of open spina bifida and 2 cases of closed spina bifida. All assays were performed before the end of the 2nd trimester and most between 15 and 20 wk of pregnancy. .beta.-Lipoprotein was compared with .alpha.-fetoprotein and .alpha.2-macroglobulin in its effectiveness in diagnosing spina bifida early enough to allow a termination of pregnancy.

引用

页码：401 / 408

页数：8

共 22 条

[11]

CARTER CO, 1974, DEV MED CHILD NEUROL, V16, P3

[12]

EMERY AEH, 1974, J OBSTET GYN BR COMM, V81, P512

[13]

FIELD B, 1975, LANCET, V2, P324

[14]

LAURENCE KM, 1975, LANCET, V2, P80

[15]

MACRI JN, 1974, LANCET, V1, P1109

[16]

NEVIN NC, 1974, J OBSTET GYN BR COMM, V81, P557

[17]

PURDIE DW, 1975, LANCET, V1, P1013

[18]

RENWICK JH, 1972, BRIT J PREV SOC MED, V26, P67

[19] AMNIOTIC-FLUID ALPHA 1 FETOPROTEIN IN DIAGNOSIS OF NEURAL TRACT MALFORMATIONS [J].

STEWART, CR ;

WARD, AM ;

LORBER, J .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1975, 82 (04) :257-261

[20]

SUTCLIFFE RG, 1973, J OBSTET GYN BR COMM, V80, P721

← 1 2 3 →