THE C-SRC TYROSINE KINASE (CSK) GENE, A POTENTIAL ANTIONCOGENE, LOCALIZES TO HUMAN-CHROMOSOME REGION 15Q23-]Q25

被引：13

作者：

ARMSTRONG, E

CANNIZZARO, L

BERGMAN, M

HUEBNER, K

ALITALO, K

机构：

[1] UNIV HELSINKI,DEPT PATHOL,CANC BIOL LAB,SF-00290 HELSINKI 29,FINLAND

[2] THOMAS JEFFERSON UNIV,JEFFERSON CANC INST,PHILADELPHIA,PA 19107

来源：

CYTOGENETICS AND CELL GENETICS | 1992年 / 60卷 / 02期

关键词：

D O I：

10.1159/000133318

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have previously reported the cloning of a novel cytoplasmic tyrosine kinase, CSK. This tyrosine kinase has been shown to downregulate the tyrosine kinase activity of the c-src oncoprotein through tyrosine phosphorylation of the c-src carboxyl terminus. Cell transformation by src oncoproteins is caused by several oncogenic mechanisms, which interfere with this phosphorylation. The CSK gene could therefore potentially function as an antioncogene. We have here mapped the CSK gene to 15q23 --> q25 by in situ hybridization.

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页码：119 / 120

页数：2

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