AUTOIMMUNE THROMBOCYTOPENIA - ANTI-GLYCOPROTEIN IIB/IIIA AUTO ANTIBODIES ARE REDUCED AFTER HUMAN ANTI-D IMMUNOGLOBULIN TREATMENT

被引：12

作者：

BOUGHTON, BJ

COOKE, RMS

SMITH, NA

SIMPSON, AW

机构：

[1] Department ofHaematology, University of Birmingham Medical School Edgbaston Birmingham

[2] The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto

来源：

AUTOIMMUNITY | 1994年 / 18卷 / 02期

关键词：

AITP; ANTI-D IMMUNOGLOBULIN; MAIPA; ANTI-GLYCOPROTEIN ANTIBODIES;

D O I：

10.3109/08916939409007987

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In chronic autoimmune thrombocytopenic purpura (AITP), an indirect monoclonal antibody immobilised platelet antigen (MAIPA) assay detected serum glycoprotein (GP) IIb/IIIa antibodies in 16/39 (41%) cases. In patients with clinically active AITP, a direct MAIPA assay detected platelet-associated GP IIb/IIIa kantibodies in 8/13 (62%) cases. Platelet bound and serum antibody concentrations suggested a high antibody affinity for platelet membrane glycoprotein IIb/IIIa. Five AITP patients with platelet associated glycoprotein IIb/IIIa antibodies were treated with intravenous anti D immunoglobulin. All showed an increase in platelet counts and a decrease in platelet associated autoantibody. These responses could be due to immunosuppressive anti-idiotype antibodies in anti D immunoglobulin.

引用

页码：141 / 144

页数：4

共 19 条

[1] Fchr J., Hoffman V., Kappeler U.N., Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high dose intravenous immunoglobulin, New Eng. J, 306, pp. 1254-1258, (1982)
[2] Smith N.A., Chakraverhty R.K., Boughton B.J., The successful treatment of idioptathic thrombocytopenic purpura with the low dose non specific IgG component of anti-D immunoglobulin, Clin. Lab. Haem, 12, pp. 131-136, (1990)
[3] Debre M., Bonnet M.C., Fridman W.H., Carosella E., Phillippe N., Reihert P., Vilmer E., Kaplan C., Teillaud J.C., Griscelli C., Infusion of Fc fragments for treatment of children with acute immune thrombocytopenic purpura, Lancet, 342, pp. 945-949, (1993)
[4] Bierling P., Divine M., Farcet J.P., Wallet P., Duedari N., Persistent remission of adult chronic autoimmune thrombocytopenic purpura after treatment with high-dose intravenous immunoglobulin, Amer. J. Haematol, 25, pp. 271-275, (1987)
[5] Atrah H.I., Davidson R.J.L., Mechanism of action of intravenous immunoglobulin in immune-mediated cytopenias, J. Clin. Path, 41, pp. 1249-1255, (1988)
[6] Smith N.A., Chakraverty R.K., Obeid D., Boughton B.J., Long term response in a patient with idiopathic thrombocytopenic purpura following low dose anti-D immunoglobulin treatment, Autoimmunity, 4, pp. 115-117, (1989)
[7] Smith N., Ng J.P., Boughton B.J., Prolonged response to nonspecific intramuscular immunoglobulin treatment in patients with ITP, Brit. J. Haematol, 77, (1991)
[8] Rossi F., Kazatchkine M.D., Anti-idiotypes against autoantibodies in pooled normal human polyspecific Ig, J. Immunol, 143, pp. 4104-4109, (1989)
[9] Berchtold P., Dale G.L., Tani P., McMillan R., Inhibition of autoantibody binding to platelet GPIIb/IIIa by antiidiotype antibodies in intravenous gammaglobulin, Blood, 74, pp. 2414-2417, (1989)
[10] Normura S., Yanabu N., Soga T., Kido H., Fokuroi T., Ya-Maguehi K., Nagata H., Kokawa T., Yasunaga K., Analysis of idiopathic thrombocytopenic purpura patients with anti glycoprotein Ilb/IIIa or lb autoantibodies, Acta Haemato-logica, 86, pp. 25-30, (1991)

← 1 2 →