AUTOIMMUNE THROMBOCYTOPENIA - ANTI-GLYCOPROTEIN IIB/IIIA AUTO ANTIBODIES ARE REDUCED AFTER HUMAN ANTI-D IMMUNOGLOBULIN TREATMENT

被引：12

作者：

BOUGHTON, BJ

COOKE, RMS

SMITH, NA

SIMPSON, AW

机构：

[1] Department ofHaematology, University of Birmingham Medical School Edgbaston Birmingham

[2] The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto

来源：

AUTOIMMUNITY | 1994年 / 18卷 / 02期

关键词：

AITP; ANTI-D IMMUNOGLOBULIN; MAIPA; ANTI-GLYCOPROTEIN ANTIBODIES;

D O I：

10.3109/08916939409007987

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In chronic autoimmune thrombocytopenic purpura (AITP), an indirect monoclonal antibody immobilised platelet antigen (MAIPA) assay detected serum glycoprotein (GP) IIb/IIIa antibodies in 16/39 (41%) cases. In patients with clinically active AITP, a direct MAIPA assay detected platelet-associated GP IIb/IIIa kantibodies in 8/13 (62%) cases. Platelet bound and serum antibody concentrations suggested a high antibody affinity for platelet membrane glycoprotein IIb/IIIa. Five AITP patients with platelet associated glycoprotein IIb/IIIa antibodies were treated with intravenous anti D immunoglobulin. All showed an increase in platelet counts and a decrease in platelet associated autoantibody. These responses could be due to immunosuppressive anti-idiotype antibodies in anti D immunoglobulin.

引用

页码：141 / 144

页数：4

共 19 条

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