POTENTIAL INTERACTIONS BETWEEN ESTROGEN-RECEPTOR AND THYROID RECEPTORS RELEVANT FOR NEUROENDOCRINE SYSTEMS

被引:24
作者
DELLOVADE, TL [1 ]
ZHU, YS [1 ]
PFAFF, DW [1 ]
机构
[1] ROCKEFELLER UNIV, NEUROBIOL & BEHAV LAB, NEW YORK, NY 10021 USA
关键词
D O I
10.1016/0960-0760(95)00037-Z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Environmental signals can profoundly affect reproductive behavior, physiology and responses to steroids. One consequence of nutritional or temperature stress is altered plasma concentrations of thyroid hormone. Recent in vivo and in vitro data indicate that manipulations of estrogen and thyroid hormone levels can alter each other's functions. One possible mechanism for interaction may be that thyroid and estrogen receptors bind to parts of the same hormone response elements of target genes and compete with each other, thus serving to integrate environmental signals with neuroendocrine responses.
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页码:27 / 31
页数:5
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共 54 条
  • [31] Adan, Cox, van Kats, Burbach, Thyroid hormone regulates the oxytocin gene, J. Biol. Chem., 267, pp. 3771-3777, (1992)
  • [32] Adan, Cox, Beischlag, Burbach, A composite hormone response element mediates the transactivation of the rat oxytocin gene by different classes of nuclear hormone receptors, Molec. Endocr., 7, pp. 47-57, (1993)
  • [33] Lucas, Granner, Hormone response domains in gene transcription, Ann. Rev. Biochem., 61, pp. 1131-1173, (1992)
  • [34] Marks, Levi, Segars, Driggers, Hirschfeld, Nagata, Ozato, H-2RIIBP expressed from baculovirus vector binds to multiple hormone response elements, Molec. Endocr., 6, pp. 219-230, (1992)
  • [35] Marks, Hallenbeck, Nagata, Segars, Appella, Nickodem, Ozato, H-2RIIBP (RXRβ) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes, EMBO J., 11, pp. 1419-1435, (1992)
  • [36] Bugge, Pohl, Lonnoy, Stunnenberg, RXRα, a promiscuous partner of retinoic acid and thyroid hormone receptors, EMBO J., 11, pp. 1409-1418, (1992)
  • [37] Kliewer, Umesono, Mangelsdorf, Evans, Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D<sub>3</sub> signalling, Nature, 355, pp. 446-449, (1992)
  • [38] Yu, Delsert, Andersen, Holloway, Devary, Naar, Kim, Boutin, Glass, Rosenfeld, RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements, Cell, 67, pp. 1251-1266, (1991)
  • [39] Segars, Marks, Hirschfeld, Driggers, Martinez, Grippo, Wahli, Ozato, Inhibition of estrogen-responsive gene activation by the retinoid X receptor β: evidence for multiple inhibitory pathways, Molec. Cell. Biol., 13, pp. 2258-2268, (1993)
  • [40] Romano, Harlan, Shivers, Howells, Pfaff, Estrogen increases proenkephalin messenger ribonucleic acid levels in the ventromedial hypothalamus of the rat, Molec. Endocr., 2, pp. 1320-1328, (1988)