GLUCOCORTICOID INDUCTION OF RAT ANGIOTENSIN-II TYPE 1A RECEPTOR GENE PROMOTER

被引：22

作者：

UNO, S

GUO, DF

NAKAJIMA, M

OHI, H

IMADA, T

HIRAMATSU, R

NAKAKUBO, H

NAKAMURA, N

INAGAMI, T

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

[2] GREEN CROSS CO,DIV RES,HIRAKATA,OSAKA,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 204卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2446

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Promoter/luciferase reporter analysis indicated that the 5'-flanking region of rat angiotensin II type 1A receptor gene was functional, both in the rat aortic smooth muscle cells (RASMCs) and in Y1 cells derived from mouse adrenal cortex. In response to dexamethasone (Dex), transcriptional activity of promoter increased in transfected RASMCs, suggesting the functional cis-action of a glucocorticoid responsive elements (GRE). Furthermore, the expression of the rat AT(1A) gene was also upregulated by Dex at the levels of both mRNA and protein in RASMCs. (C) 1994 Academic Inc. Press.

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收藏

页码：210 / 215

页数：6

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