ROLE OF CD8+ IN LATE OPPORTUNISTIC INFECTIONS OF PATIENTS WITH AIDS

We studied the relationship of CD4+ and CD8+ depletion to initial and late opportunistic infections in 62 patients with AIDS. The mean interval between initial and late infections was 12.2 months. Geometric mean (and 95 % confidence intervals) of T-cell counts at the diagnosis of each infection were: (Pneumocystis carinii pneumonia) CD4+ 0.051 (0.044-0.058) x 10(9)/l, CD8+ 0.561 (0.476-0.646) x 10(9)/l; (cytomegalovirus retinitis) CD4+ 0.025 (0.019-0.031) x 10(9)/l, CD8+ 0.333 (0.183-0.483) x 10(9)/l. Mycobacterium avium-intracellulare bacteraemia closely followed cytomegalovirus dissemination. Most patients were free from late opportunistic infections caused by disseminated cytomegalovirus and M. avium-intracellulare until CD8+ declined below 0.500 x 10(9)/l. Zidovudine improved CD4+, but less so CD8+, and similarly enhanced the survival of patients treated in 1985-1990 and 1991.