ENDOTHELIN-3 STIMULATES THE RELEASE OF CATECHOLAMINE FROM CORTICAL AND STRIATAL SLICES OF THE RAT

被引：38

作者：

KOIZUMI, S

KATAOKA, Y

NIWA, M

KUMAKURA, K

机构：

[1] SOPHIA UNIV,INST LIFE SCI,7-1 KIOI CHO,CHIYODA KU,TOKYO 102,JAPAN

[2] KYUSHU UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,FUKUOKA 812,JAPAN

[3] NAGASAKI UNIV,SCH MED,DEPT PHARMACOL 2,NAGASAKI 852,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 134卷 / 02期

关键词：

ENDOTHELIN; CATECHOLAMINE RELEASE; CALCIUM ANTAGONIST; STRIATUM; CORTEX; RAT;

D O I：

10.1016/0304-3940(92)90521-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Endothelin-3 (ET-3) evoked the release of dopamine/noradrenaline from cortical slices and dopamine from striatal slices in a concentration-dependent manner. This action peaked slowly and was long-lasting in real-time monitoring, being different from the high K+-evoked response. The striatal response to 10-mu-M of ET-3 was reduced by extracellular Ca2+ depletion to 40% of control and by Ca2+ antagonists, especially nifedipine and flunarizine, to 40% of control. Our findings suggest that ET has a physiological significance in the brain as a neuromodulator for catecholaminergic transmission.

引用

页码：219 / 222

页数：4

共 17 条

[1] DIHYDROPYRIDINE-SENSITIVE LOW-THRESHOLD CALCIUM CHANNELS IN ISOLATED RAT HYPOTHALAMIC NEURONS [J].