THE MO15 CELL-CYCLE KINASE IS ASSOCIATED WITH THE TFIIH TRANSCRIPTION DNA-REPAIR FACTOR

被引：413

作者：

ROY, R

ADAMCZEWSKI, JP

SEROZ, T

VERMEULEN, W

TASSAN, JP

SCHAEFFER, L

NIGG, EA

HOEIJMAKERS, JHJ

EGLY, JM

机构：

[1] INST GENET & BIOL MOLEC & CELLULAIRE, CNRS, INSERM, F-67404 ILLKIRCH GRAFFENSTADEN, FRANCE

[2] ERASMUS UNIV ROTTERDAM, CTR MED GENET, DEPT CELL BIOL & GENET, 3000 DR ROTTERDAM, NETHERLANDS

[3] SWISS INST EXPTL CANC RES, CH-1066 EPALINGES, SWITZERLAND

来源：

CELL | 1994年 / 79卷 / 06期

关键词：

D O I：

10.1016/0092-8674(94)90039-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A protein kinase activity that phosphorylates the G-terminal domain (CTD) of RNA polymerase II and is associated with the basal transcription-repair factor TFIIH (also called BTF2) resides with MO15, a cyclin-dependent protein kinase that was first found to be involved in cell cycle regulation. Using in vivo and in vitro repair assays, we show that MO15 is important for nucleotide excision repair, most likely through its association with TFIIH, thus providing an unexpected link among three important cellular mechanisms.

引用

页码：1093 / 1101

页数：9

共 33 条

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