EVOLUTION OF H3N8 EQUINE INFLUENZA-VIRUS FROM 1963 TO 1991

被引：24

作者：

OXBURGH, L ^{[1
]}

BERG, M ^{[1
]}

KLINGEBORN, B ^{[1
]}

EMMOTH, E ^{[1
]}

LINNE, T ^{[1
]}

机构：

[1] NATL VET INST,CTR BIOMED,DEPT VIROL,S-75123 UPPSALA,SWEDEN

来源：

VIRUS RESEARCH | 1994年 / 34卷 / 02期

关键词：

EQUINE INFLUENZA VIRUS H3N8; VIRUS EVOLUTION; HEMAGGLUTINATION;

D O I：

10.1016/0168-1702(94)90097-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antigenic properties of H3N8 influenza viruses isolated from outbreaks of equine influenza in Sweden between 1979 and 1991 have been studied in hemagglutination inhibition tests with polyclonal and monoclonal antisera, and antigenic drift of the virus has been demonstrated. To clarify the basis of the antigenic drift, amino acid sequences of the globular head regions (HA1) of the hemagglutinin membrane glycoproteins of virus strains from 1979, 1984, 1988 and 1990 have been deduced from the nucleotide sequences of the hemagglutinin genes, and the sequence information has been used to construct a phylogenetic tree of H3N8 equine influenza strains. Several strains from previous studies have been included to give a clearer picture of viral evolution in an international context.

引用

页码：153 / 165

页数：13

共 17 条

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