INTERACTIONS BETWEEN TEMPERATURE-SENSITIVE HYDROGEL MICROSPHERES AND GRANULOCYTES

被引：17

作者：

ACHIHA, K ^{[1
]}

OJIMA, R ^{[1
]}

KASUYA, Y ^{[1
]}

FUJIMOTO, K ^{[1
]}

KAWAGUCHI, H ^{[1
]}

机构：

[1] KEIO UNIV, DEPT APPL CHEM, KOHOKU KU, YOKOHAMA, KANAGAWA 223, JAPAN

来源：

POLYMERS FOR ADVANCED TECHNOLOGIES | 1995年 / 6卷 / 07期

关键词：

POLY(N-ISOPROPYIACRYLAMIDE; HYDROGEL; MICROSPHERE; GRANULOCYTE; CELL ACTIVATION;

D O I：

10.1002/pat.1995.220060715

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(N-isopropylacrylamide) (PNIPAM) has a low critical solution temperature (LCST) at 32 degrees C in water and the hydrophilicity changes through the LCST. The microspheres whose surface was composed of PNIPAM exhibited phase transition behavior around 32 degrees C. Therefore, the interactions between PNIPAM microspheres and granulocytes depended on the temperature. That is, the oxygen consumption and active oxygen production by cells in contact with PNIPAM-containing microspheres and adhesion of the microspheres to the cell surface were more enhanced above the LCST of PNIPAM than below it, whereas no significant temperature dependence of cell-microspheres interaction was observed in non-thermosensitive microsphere systems. If was suggested that the function of cells could be controlled with temperature using the temperature-sensitive microspheres.

引用

页码：534 / 540

页数：7

共 19 条

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