ANTIBIOTIC KINETICS AND DYNAMICS FOR THE CLINICIAN

被引：41

作者：

NICOLAU, DP

QUINTILIANI, R

NIGHTINGALE, CH

机构：

[1] HARTFORD HOSP,DEPT PHARM,HARTFORD,CT 06102

[2] HARTFORD HOSP,DEPT RES ADM,HARTFORD,CT 06102

[3] UNIV CONNECTICUT,SCH MED,DEPT MED,FARMINGTON,CT

[4] UNIV CONNECTICUT,SCH PHARM,STORRS,CT

来源：

MEDICAL CLINICS OF NORTH AMERICA | 1995年 / 79卷 / 03期

关键词：

D O I：

10.1016/S0025-7125(16)30051-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In recent decades considerable data have been acquired concerning the complex interactions of the organism-antimicrobial-host triad. Using the current understanding of drug disposition in the body, pharmacokinetics, and in vitro microbiologic activity, optimal dosing strategies can be derived to maximize clinical efficacy and minimize potential toxicities. This article discusses pharmacokinetics, pharmadynamics, and the application of this principle in clinical practice.

引用

页码：477 / 495

页数：19

共 45 条

[1] ANALYSIS OF VANCOMYCIN TIME-KILL STUDIES WITH STAPHYLOCOCCUS SPECIES BY USING A CURVE STRIPPING PROGRAM TO DESCRIBE THE RELATIONSHIP BETWEEN CONCENTRATION AND PHARMACODYNAMIC RESPONSE [J].