ENEDIYNE COMPOUNDS EQUIPPED WITH ACID-SENSITIVE, BASE-SENSITIVE AND PHOTO-SENSITIVE TRIGGERING DEVICES - CHEMICAL SIMULATION OF THE DYNEMICIN A REACTION CASCADE

被引：86

作者：

NICOLAOU, KC ^{[1
]}

DAI, WM ^{[1
]}

WENDEBORN, SV ^{[1
]}

SMITH, AL ^{[1
]}

TORISAWA, Y ^{[1
]}

MALIGRES, P ^{[1
]}

HWANG, CK ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, DEPT CHEM, LA JOLLA, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 08期

关键词：

D O I：

10.1002/anie.199110321

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Even under very mild basic conditions, the NH compound 2 is generated from the enediyne 1. Compound 2 proved too labile to be isolated, but could be trapped with nucleophiles such as PhOH and PhSH, resulting in the formation of the dibenzo compounds 4 (via 3), among other products. Compounds 2—like several other newly synthesized compounds—exhibits DNA‐cleaving activity. (Figure Presented.) Copyright © 1991 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1032 / 1036

页数：5

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