NUCLEAR SIGNALING BY INTERLEUKIN-6

被引：43

作者：

CHENKIANG, S

HSU, W

NATKUNAM, Y

ZHANG, XK

机构：

[1] Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 01期

关键词：

D O I：

10.1016/0952-7915(93)90091-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular analysis of the regulation of nuclear proteins induced by interleukin-6 has provided new insights into this largely unknown signal transduction pathway. Transcription factors of the CCAAT/enhancer-binding protein and AP-1 families, as well as the octamer-binding proteins and the tumor suppressor gene product pRB, are regulated by interleukin-6 in a cell type specific manner, suggesting that they may play a role in the nuclear signaling by interleukin-6.

引用

收藏

页码：124 / 128

页数：5

相关论文

共 39 条

[21] LEUKEMIA INHIBITORY FACTOR AND INTERLEUKIN-6 TRIGGER THE SAME IMMEDIATE EARLY RESPONSE, INCLUDING TYROSINE PHOSPHORYLATION, UPON INDUCTION OF MYELOID-LEUKEMIA DIFFERENTIATION [J].

LORD, KA ;

ABDOLLAHI, A ;

THOMAS, SM ;

DEMARCO, M ;

BRUGGE, JS ;

HOFFMANLIEBERMANN, B ;

LIEBERMANN, DA .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (09) :4371-4379

[22] CAMP STIMULATES THE C/EBP-RELATED TRANSCRIPTION FACTOR RNFIL-6 TO TRANS-LOCATE TO THE NUCLEUS AND INDUCE C-FOS TRANSCRIPTION [J].

METZ, R ;

ZIFF, E .

GENES & DEVELOPMENT, 1991, 5 (10) :1754-1766

[23] INTERLEUKIN-6 SIGNALS ACTIVATING JUNB AND TIS11 GENE-TRANSCRIPTION IN A B-CELL HYBRIDOMA [J].

NAKAJIMA, K ;

WALL, R .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (03) :1409-1418

[24]

NATSUKA S, 1992, BLOOD, V79, P460

[25] AUGMENTATION OF HAPTOGLOBIN PRODUCTION IN HEP3B CELL-LINE BY A NUCLEAR FACTOR NF-IL6 [J].

NATSUKA, S ;

ISSHIKI, H ;

AKIRA, S ;

KISHIMOTO, T .

FEBS LETTERS, 1991, 291 (01) :58-62

[26] IL-6DBP, A NUCLEAR-PROTEIN INVOLVED IN INTERLEUKIN-6 SIGNAL TRANSDUCTION, DEFINES A NEW FAMILY OF LEUCINE ZIPPER PROTEINS RELATED TO C/EBP [J].

POLI, V ;

MANCINI, FP ;

CORTESE, R .

CELL, 1990, 63 (03) :643-653

[27] INTERLEUKIN-6 INDUCES SECRETION OF IGG1 BY COORDINATED TRANSCRIPTIONAL ACTIVATION AND DIFFERENTIAL MESSENGER-RNA ACCUMULATION [J].

RAYNAL, MC ;

LIU, ZY ;

HIRANO, T ;

MAYER, L ;

KISHIMOTO, T ;

CHENKIANG, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :8024-8028

[28] INTERFERONS AND INTERLEUKIN-6 SUPPRESS PHOSPHORYLATION OF THE RETINOBLASTOMA PROTEIN IN GROWTH-SENSITIVE HEMATOPOIETIC-CELLS [J].

RESNITZKY, D ;

TIEFENBRUN, N ;

BERISSI, H ;

KIMCHI, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) :402-406

[29] IG/EBP-1 - A UBIQUITOUSLY EXPRESSED IMMUNOGLOBULIN ENHANCER BINDING-PROTEIN THAT IS SIMILAR TO C/EBP AND HETERODIMERIZES WITH C/EBP [J].

ROMAN, C ;

PLATERO, JS ;

SHUMAN, J ;

CALAME, K .

GENES & DEVELOPMENT, 1990, 4 (08) :1404-1415

[30] CHOP, A NOVEL DEVELOPMENTALLY REGULATED NUCLEAR-PROTEIN THAT DIMERIZES WITH TRANSCRIPTION FACTORS C/EBP AND LAP AND FUNCTIONS AS A DOMINANT-NEGATIVE INHIBITOR OF GENE-TRANSCRIPTION [J].

RON, D ;

HABENER, JF .

GENES & DEVELOPMENT, 1992, 6 (03) :439-453

← 1 2 3 4 →