THE EFFECT OF NIMODIPINE ON ICP AND CBF IN PATIENTS WITH NORMAL-PRESSURE HYDROCEPHALUS

被引：15

作者：

SCHMIDT, JF ^{[1
]}

ALBECK, M ^{[1
]}

GJERRIS, F ^{[1
]}

机构：

[1] UNIV COPENHAGEN,RIGSHOSP,NEUROSURG CLIN,DK-2100 COPENHAGEN O,DENMARK

来源：

ACTA NEUROCHIRURGICA | 1990年 / 102卷 / 1-2期

关键词：

cerebral blood flow; Intracranial pressure; nimodipine; perfusion pressure;

D O I：

10.1007/BF01402178

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Eight patients with normal-pressure hydrocephalus (NPH) were studied. The resting mean arterial blood pressure (MABP) was 100 (90-125)mmHg and the mean intracranial pressure (ICP) was 11 (5-17)mmHg. ICP and MABP were continuously measured intraventricularly and intra-arterially, respectively. Changes in global cerebral blood flow (CBF) were estimated by the arteriovenous oxygen difference method. Intravenous nimodipine (15 microgram/kg/hour) was given in the first 2 hours and 30 microgram/kg/hour in the next 2 hours. MABP was reduced 23 (4-47)mmHg (p<0.05). ICP was increased 3 (0-10)mmHg (p < 0.05). CBF was unchanged in the group on the whole, but in 4 of patients a major drop in perfusion pressure was seen, and CBF decreased 6, 11, 23 and 34%, respectively. Thus these findings underline the importance of maintaining the perfusion pressure under treatment with nimodipine. © 1990 Springer-Verlag.

引用

页码：11 / 13

页数：3