DESIGN AND SYNTHESIS OF A CEPHALOSPORIN CARBOPLATINUM PRODRUG ACTIVATABLE BY A BETA-LACTAMASE

被引：45

作者：

HANESSIAN, S

WANG, JG

机构：

[1] Department of Chemistry, Universite de Montreal, Montreal

来源：

CANADIAN JOURNAL OF CHEMISTRY | 1993年 / 71卷 / 06期

关键词：

D O I：

10.1139/v93-119

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The design and syntheses of two cephalosporin-carboplatinum prodrugs that can be released by a beta-lactamase are described. The hydrolysis of cephalosporins catalyzed by a beta-lactamase with acetyl or DACCP as 3'-leaving groups is studied by H-1 nuclear magnetic resonance in deuterated buffer solutions. These notions provide a new approach to the use of platinum complexes for antitumor therapy.

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页码：896 / 906

页数：11

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