MEDICAL-TREATMENT OF RASMUSSENS-SYNDROME (CHRONIC ENCEPHALITIS AND EPILEPSY) - EFFECT OF HIGH-DOSE STEROIDS OR IMMUNOGLOBULINS IN 19 PATIENTS

被引：158

作者：

HART, YM

CORTEZ, M

ANDERMANN, F

HWANG, P

FISH, DR

DULAC, O

SILVER, K

FEJERMAN, N

CROSS, H

SHERWIN, A

CARABALLO, R

机构：

[1] MONTREAL NEUROL HOSP & INST, MONTREAL H3A 2B4, PQ, CANADA

[2] HOSP SICK CHILDREN, TORONTO M5G 1X8, ON, CANADA

[3] UCL NATL HOSP NEUROL & NEUROSURG, LONDON WC1N 3BG, ENGLAND

[4] HOP ST VINCENT DE PAUL, F-75674 PARIS, FRANCE

[5] MONTREAL CHILDRENS HOSP, MONTREAL H3H 1P3, PQ, CANADA

[6] HOSP JUAN GARRAHAN, BUENOS AIRES, ARGENTINA

[7] HOSP SICK CHILDREN, LONDON WC1N 3JH, ENGLAND

来源：

NEUROLOGY | 1994年 / 44卷 / 06期

关键词：

D O I：

10.1212/WNL.44.6.1030

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We treated 19 patients with Rasmussen's syndrome (chronic encephalitis and epilepsy)-a rare progressive disorder of unknown etiology causing focal epilepsy, hemiparesis, and intellectual deterioration-with intravenous immunoglobulins, high-dose steroids, or both, to control seizures and improve the end point of the disease. Ten of 17 patients receiving steroids, and eight of nine patients receiving immunoglobulins, had some reduction of seizure frequency in the short term. Improvement in hemiparesis was slight. The effect of these drugs in ameliorating the end point of the disease in the long term remains unknown, and further multicenter studies with standardized protocols are warranted.

引用

页码：1030 / 1036

页数：7

共 28 条

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