INTRATUMORAL CHEMOTHERAPY

被引：189

作者：

WALTER, KA

TAMARGO, RJ

OLIVI, A

BURGER, PC

BREM, H

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROSURG, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21205 USA

[3] JOHNS HOPKINS UNIV, SCH MED, DEPT ONCOL, BALTIMORE, MD 21205 USA

来源：

NEUROSURGERY | 1995年 / 37卷 / 06期

关键词：

BRAIN NEOPLASMS; HEMOTHERAPY; CONTROLLED RELEASE; DRUG DELIVERY DEVICES; INTRATUMORAL INJECTIONS; POLYMERS;

D O I：

10.1227/00006123-199512000-00013

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IN AN EFFORT to improve survival from malignant gliomas, investigators have used intratumoral chemotherapy protocols to deliver high doses of tumoricidal agents directly to the brain. Theoretically, these infusions bypass the blood-brain barrier, minimize systemic drug levels and the side effects of chemotherapy, and achieve prolonged elevations of intracerebral chemotherapeutic agents relative to those obtainable by systemic administration. Almost all major classes of chemotherapeutic agents have been examined as possible intratumoral therapies via delivery approaches ranging from simple intratumoral injections to implantable computer-driven constant infusion pumps and biodegradable polymer matrices. In this review, we summarize the major clinical trials and experimental investigations underlying the development of intratumoral chemotherapy as a treatment for gliomas.

引用

页码：1129 / 1145

页数：17

共 132 条

[11] BIODEGRADABLE POLYMERS FOR CONTROLLED DELIVERY OF CHEMOTHERAPY WITH AND WITHOUT RADIATION-THERAPY IN THE MONKEY BRAIN [J].

BREM, H ;

TAMARGO, RJ ;

OLIVI, A ;

PINN, M ;

WEINGART, JD ;

WHARAM, M ;

EPSTEIN, JI .

JOURNAL OF NEUROSURGERY, 1994, 80 (02) :283-290

[12]

BREM H, 1995, IN PRESS J NEUROONCO, V26

[13]

BRIGHTMAN MW, 1971, J NEUROPATH EXP NEUR, V30, P139

[14]

BUAHIN KG, 1992, POLYM ADVAN TECHNOL, V3, P311

[15] CYTOTOXICITY OF TAXOL IN-VITRO AGAINST HUMAN AND RAT MALIGNANT BRAIN-TUMORS [J].

CAHAN, MA ;

WALTER, KA ;

COLVIN, OM ;

BREM, H .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1994, 33 (05) :441-444

[16]

CALABRESI P, 1985, PHARMACOL BASIS THER, P1240

[17] USE OF IMPLANTABLE PUMP SYSTEMS FOR INTRAARTERIAL, INTRAVENTRICULAR AND INTRATUMORAL TREATMENT OF MALIGNANT BRAIN-TUMORS [J].

CHANDLER, WF ;

GREENBERG, HS ;

ENSMINGER, WD ;

DIAZ, RF ;

JUNCK, LR ;

HOOD, TW ;

GEBARSKI, SS ;

PAGE, MA .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1988, 531 :206-212

[18]

Choti M. A., 1995, Proceedings of the American Association for Cancer Research Annual Meeting, V36, P309

[19]

COLVIN M, 1981, CANCER TREAT REP, V65, P89

[20]

COLVIN M, 1982, PHARM PRINCIPLES CAN, P276

← 1 2 3 4 5 6 7 8 9 10 →