REGULATION OF GENE EXPRESSION IN THE GENOMIC CONTEXT

被引:34
作者
Atkinson, Taylor J. [1 ,3 ]
Halfon, Marc S. [1 ,2 ,3 ,4 ,5 ]
机构
[1] SUNY Buffalo, Dept Biochem, Buffalo, NY 14203 USA
[2] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14203 USA
[3] NY State Ctr Excellence Bioinformat & Life Sci, Buffalo, NY 14203 USA
[4] Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA
[5] Roswell Pk Canc Inst, Program Canc Genet, Buffalo, NY 14263 USA
来源
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL | 2014年 / 9卷 / 13期
基金
美国国家卫生研究院;
关键词
D O I
10.5936/csbj.201401001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metazoan life is dependent on the proper temporal and spatial control of gene expression within the many cells. essentially all with the identical genome. that make up the organism. While much is understood about how individual gene regulatory elements function, many questions remain about how they interact to maintain correct regulation globally throughout the genome. In this review we summarize the basic features and functions of the crucial regulatory elements promoters, enhancers, and insulators and discuss some of the ways in which proper interactions between these elements is realized. We focus in particular on the role of core promoter sequences and propose explanations for some of the contradictory results seen in experiments aimed at understanding insulator function. We suggest that gene regulation depends on local genomic context and argue that more holistic in vivo investigations that take into account multiple local features will be necessary to understand how genome-wide gene regulation is maintained.
引用
收藏
页数:9
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