PINEAL SEROTONIN N-ACETYLTRANSFERASE - EXPRESSION CLONING AND MOLECULAR ANALYSIS

被引：304

作者：

COON, SL

ROSEBOOM, PH

BALER, R

WELLER, JL

NAMBOODIRI, MAA

KOONIN, EV

KLEIN, DC

机构：

[1] NICHHD, DEV NEUROBIOL LAB, NEUROBIOL SECT, BETHESDA, MD 20892 USA

[2] GEORGETOWN UNIV, DEPT BIOL, WASHINGTON, DC 20057 USA

[3] NATL LIB MED, NATL CTR BIOTECHNOL INFORMAT, BETHESDA, MD 20894 USA

来源：

SCIENCE | 1995年 / 270卷 / 5242期

关键词：

D O I：

10.1126/science.270.5242.1681

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pineal serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, or AA-NAT) generates the large circadian rhythm in melatonin, the hormone that coordinates daily and seasonal physiology in some mammals. Complementary DNA encoding ovine AA-NAT was cloned. The abundance of AA-NAT messenger RNA (mRNA) during the day was high in the ovine pineal gland and somewhat lower in retina. AA-NAT mRNA was found unexpectedly in the pituitary gland and in some brain regions. The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases.

引用

页码：1681 / 1683

页数：3

共 37 条

[21] NAMBOODIRI MAA, 1980, J BIOL CHEM, V255, P6032
[22] NAMBOODIRI MAA, 1984, J COMP BIOCH B, V80, P731
[23] O'Brien PJ, 1986, PINEAL RETINAL RELAT
[24] RIODAN JF, 1972, METHODS ENZYMOL B, V25, P494
[25] RADIOIMMUNOASSAY OF SERUM CONCENTRATIONS OF MELATONIN IN SHEEP EXPOSED TO DIFFERENT LIGHTING REGIMENS
ROLLAG, MD
NISWENDER, GD
[J]. ENDOCRINOLOGY, 1976, 98 (02) : 482 - 489
[26] ROSEBOOM PH, UNPUB
[27] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS
SANGER, F
NICKLEN, S
COULSON, AR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5463 - 5467
[28] A WORKBENCH FOR MULTIPLE ALIGNMENT CONSTRUCTION AND ANALYSIS
SCHULER, GD
ALTSCHUL, SF
LIPMAN, DJ
[J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1991, 9 (03): : 180 - 190
[29] SCHULZ GE, 1992, CURR OPIN STRUC BIOL, V2, P61
[30] N-ACETYLTRANSFERASE AND MELATONIN IN THE RETINA - REGULATION, FUNCTION AND MODE OF ACTION
SKENE, DJ
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1992, 20 (02) : 312 - 315

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