THE GENOMIC ORGANIZATION AND DNA-SEQUENCE OF THE MOUSE VAS-DEFERENS ANDROGEN-REGULATED PROTEIN GENE

被引：25

作者：

PAILHOUX, E ^{[1
]}

VEYSSIERE, G ^{[1
]}

FABRE, S ^{[1
]}

TOURNAIRE, C ^{[1
]}

JEAN, C ^{[1
]}

机构：

[1] UNIV CLERMONT FERRAND,CNRS,URA 360,LES CEZEAUX,F-63177 CLERMONT FERRAND,FRANCE

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1992年 / 42卷 / 06期

关键词：

D O I：

10.1016/0960-0760(92)90445-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene for mouse vas deferens protein (MVDP) is expressed, under androgenic control, exclusively in the epithelial cells of the deferent duct. As a first step in correlating cell-specific and hormonal regulations with the structure of the gene, the complete sequence of the MVDP gene (11 kb) and 0.5 kb of the 5' flanking region have been determined. The size range for the 10 exons is 78 to 168 bp, whereas that of introns is 292 to 2833 bp. A major site of transcription is located on an A residue 46 nucleotides upstream from the A of the ATG initiation codon. A TATA (CATAA) box, a CAAT box, a GC-rich motif and a (5'-TGTTCT-3') element that closely resembles the consensus sequence of the androgen response elements are present in the 5' flanking region of the MVDP gene.

引用

页码：561 / 568

页数：8

共 46 条

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