TITANATE-CATALYZED ENANTIOSELECTIVE ADDITION OF DIALKYLZINC COMPOUNDS - GENERATED INSITU FROM GRIGNARD-REAGENTS IN ETHER TO ALDEHYDES

被引：107

作者：

SEEBACH, D

BEHRENDT, L

FELIX, D

机构：

[1] Laboratorium Für Organische Chemie, Eidgenössischen Technischen Hochschule, Eth-Zentrum, CH-8092

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 08期

关键词：

D O I：

10.1002/anie.199110081

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Since manipulation of alkylzinc compounds is not always safe, it is of great advantage to prepare these from Grignard reagents in situ and then to add them to aldehydes in a one-pot procedure. The resulting secondary alcohols (e.g., 1, R from Grignard reagent) are obtained with high enantiomeric excess (90-98% ee).

引用

页码：1008 / 1009

页数：2

共 24 条

[1]

Barbier P., 1899, CR HEBD ACAD SCI, V128, P110

[2]

Frankland E, 1849, LIEBIGS ANN CHEM, V71, P171

[3]

Grignard V, 1900, CR HEBD ACAD SCI, V130, P1322

[4]

Grob K., 1986, MAKING MANIPULATING