PLASMA OSTEOCALCIN CONCENTRATIONS IN CATTLE UNDER VARIOUS PATHOPHYSIOLOGICAL CONDITIONS

被引：8

作者：

DAVICCO, MJ ^{[1
]}

COXAM, V ^{[1
]}

ROUX, R ^{[1
]}

BARLET, JP ^{[1
]}

机构：

[1] INRA,MINERAL METAB,F-63122 CEYRAT,FRANCE

来源：

BONE AND MINERAL | 1990年 / 10卷 / 02期

关键词：

Bone; Cattle; Hypocalcaemia; Osteocalcin;

D O I：

10.1016/0169-6009(90)90088-W

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma osteocalcin (BGP) concentrations were measured using an homologous radioimmunoassay in plasma samples (n = 6-14 per group) from fetal and newborn calves, 16-month-old heifers and bulls, and pregnant lactating cows. The highest values (nM) (62 ± 3) were measured in fetal calves and the lowest (15 ± 3) in 9-year-old pregnant and lactating cows. No significant relationship could be demonstrated between plasma BGP and somatomedin C, or 1,25(OH)2D or calcium concentrations. In eight normally calving cows, parturition was followed by a progressive increase in plasma BGP concentration, maximum 3 days after calving. It returned to prepartum values 10 days later. In six parturient hypocalcaemic and paretic cows, hypocalcaemia occurring within 12 h following calving was associated with a prompt and very transient increase in plasma BGP concentrations. These results indicate that osteocalcin might play a role in the regulation of bone metabolism in cattle. © 1990.

引用

页码：131 / 137

页数：7

共 27 条

[21] RADIOIMMUNOASSAY FOR THE VITAMIN K-DEPENDENT PROTEIN OF BONE AND ITS DISCOVERY IN PLASMA [J].