ORAL IMMUNIZATION - TURNING FANTASY INTO REALITY

被引：17

作者：

MANGANARO, M ^{[1
]}

OGRA, PL ^{[1
]}

ERNST, PB ^{[1
]}

机构：

[1] UNIV TEXAS, MED BRANCH, DEPT PEDIAT, GALVESTON, TX 77550 USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 103卷 / 03期

关键词：

MUCOSAL VACCINES; ORAL TOLERANCE; SECRETORY IGA; COMMON MUCOSAL SYSTEM; ORAL IMMUNIZATION;

D O I：

10.1159/000236632

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The application of oral immunization as the primary means to deliver multivalent vaccines to large populations has many theoretical advantages. However, widespread success in achieving protective immunity against these diseases through oral immunization requires additional understanding of the basic mechanisms of host resistance in the mucosal tissues. Fundamental issues, such as the lineage and repertoire or regulatory pathway of mucosal effector cells, are only now just beginning to be understood. A more comprehensive understanding of these issues could greatly enhance our success at designing and applying successful oral immunization programs.

引用

页码：223 / 233

页数：11

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