ORAL IMMUNIZATION - TURNING FANTASY INTO REALITY

被引：17

作者：

MANGANARO, M ^{[1
]}

OGRA, PL ^{[1
]}

ERNST, PB ^{[1
]}

机构：

[1] UNIV TEXAS, MED BRANCH, DEPT PEDIAT, GALVESTON, TX 77550 USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 103卷 / 03期

关键词：

MUCOSAL VACCINES; ORAL TOLERANCE; SECRETORY IGA; COMMON MUCOSAL SYSTEM; ORAL IMMUNIZATION;

D O I：

10.1159/000236632

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The application of oral immunization as the primary means to deliver multivalent vaccines to large populations has many theoretical advantages. However, widespread success in achieving protective immunity against these diseases through oral immunization requires additional understanding of the basic mechanisms of host resistance in the mucosal tissues. Fundamental issues, such as the lineage and repertoire or regulatory pathway of mucosal effector cells, are only now just beginning to be understood. A more comprehensive understanding of these issues could greatly enhance our success at designing and applying successful oral immunization programs.

引用

页码：223 / 233

页数：11

共 82 条

[11] HEPATIC SUPPRESSION OF SENSITIZATION TO ANTIGEN ABSORBED INTO PORTAL SYSTEM [J].

CANTOR, HM ;

DUMONT, AE .

NATURE, 1967, 215 (5102) :744-&

[12]

CARDENAS L, 1992, CLIN MICROBIOL REV, V5, P328

[13]

CHASE MW, 1946, P SOC EXP BIOL MED, V61, P257

[14] TRANSFORMING GROWTH FACTOR-BETA SPECIFICALLY ENHANCES IGA PRODUCTION BY LIPOPOLYSACCHARIDE-STIMULATED MURINE LYMPHOCYTES-B [J].

COFFMAN, RL ;

LEBMAN, DA ;

SHRADER, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (03) :1039-1044

[15] PEYERS PATCHES - ENRICHED SOURCE OF PRECURSORS FOR IGA-PRODUCING IMMUNOCYTES IN RABBIT [J].

CRAIG, SW ;

CEBRA, JJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1971, 134 (01) :188-&

[16] RESPIRATORY IMMUNITY STIMULATED BY INTESTINAL IMMUNIZATION WITH PURIFIED NONTYPABLE HAEMOPHILUS-INFLUENZAE ANTIGENS [J].

CRIPPS, AW ;

TAYLOR, DC ;

WALLACE, FJ ;

CLANCY, RL .

JOURNAL OF INFECTIOUS DISEASES, 1992, 165 :S199-S201

[17] IGA ANTIBODY-PRODUCING CELLS IN PERIPHERAL-BLOOD AFTER ANTIGEN INGESTION - EVIDENCE FOR A COMMON MUCOSAL IMMUNE-SYSTEM IN HUMANS [J].

CZERKINSKY, C ;

PRINCE, SJ ;

MICHALEK, SM ;

JACKSON, S ;

RUSSELL, MW ;

MOLDOVEANU, Z ;

MCGHEE, JR ;

MESTECKY, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2449-2453

[18] ROLE OF LYMPHOCYTES-T IN INTESTINAL MUCOSAL INJURY - INFLAMMATORY CHANGES IN ATHYMIC NUDE RATS [J].

DINCA, R ;

ERNST, P ;

HUNT, RH ;

PERDUE, MH .

DIGESTIVE DISEASES AND SCIENCES, 1992, 37 (01) :33-39

[19] BIODEGRADABLE POLY(DL-LACTIDE-CO-GLYCOLIDE) MICROSPHERES [J].

ELDRIDGE, JH ;

STAAS, JK ;

TICE, TR ;

GILLEY, RM .

RESEARCH IN IMMUNOLOGY, 1992, 143 (05) :557-563

[20]

ELDRIDGE JH, 1990, ADV EXP MED BIOL, V251, P191

← 1 2 3 4 5 6 7 8 9 →