STRUCTURE DETERMINATION OF ADDUCTS FROM THE REACTION OF (R)-GLYCIDALDEHYDE AND GUANOSINE

被引：14

作者：

GOLDING, BT ^{[1
]}

KENNEDY, G ^{[1
]}

WATSON, WP ^{[1
]}

机构：

[1] SHELL RES LTD,SITTINGBOURNE RES CTR,SITTINGBOURNE ME9 8AG,KENT,ENGLAND

来源：

CARCINOGENESIS | 1990年 / 11卷 / 05期

关键词：

D O I：

10.1093/carcin/11.5.865

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The structures of the initial adducts formed In the reactions of guanosine or deoxyguanosine with (R)-glycidaldehyde have been determined and compared with those obtained from racemic glycidaldehyde. A new stable adduct has also been identified which is a potential biomarker for glycidaldehyde interactions with DNA. Mechanisms are proposed to account for the formation of all the observed products. The results provide information on the molecular basis for the geno toxicity of glycidaldehyde and compounds which generate this reactive aldehyde in vivo. © 1990 Oxford University Press.

引用

页码：865 / 868

页数：4