PROTEINS WITH SH2 AND SH3 DOMAINS COUPLE RECEPTOR TYROSINE KINASES TO INTRACELLULAR SIGNALING PATHWAYS

被引：51

作者：

PAWSON, T ^{[1
]}

OLIVIER, P ^{[1
]}

ROZAKISADCOCK, M ^{[1
]}

MCGLADE, J ^{[1
]}

HENKEMEYER, M ^{[1
]}

机构：

[1] UNIV TORONTO, DEPT MOLEC & MED GENET, TORONTO M5S 1A1, ONTARIO, CANADA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1993年 / 340卷 / 1293期

关键词：

D O I：

10.1098/rstb.1993.0069

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The targets of receptor protein-tyrosine kinases are characterized by Src homology 2 (SH2) domains, that mediate specific interactions with receptor autophosphorylation sites. SH2-mediated interactions are important for the activation of biochemical signalling pathways in cells stimulated with growth factors. A distinct protein module, the SH3 domain, is frequently found in polypeptides that contain SH2 domains, and is also implicated in controlling protein-protein interactions in signal transduction. Evidence suggesting that SH2 and SH3 domains act synergistically in stimulation of the Ras pathway is discussed.

引用

页码：279 / 285

页数：7

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