PROTEINS WITH SH2 AND SH3 DOMAINS COUPLE RECEPTOR TYROSINE KINASES TO INTRACELLULAR SIGNALING PATHWAYS

被引:51
作者
PAWSON, T [1 ]
OLIVIER, P [1 ]
ROZAKISADCOCK, M [1 ]
MCGLADE, J [1 ]
HENKEMEYER, M [1 ]
机构
[1] UNIV TORONTO, DEPT MOLEC & MED GENET, TORONTO M5S 1A1, ONTARIO, CANADA
关键词
D O I
10.1098/rstb.1993.0069
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The targets of receptor protein-tyrosine kinases are characterized by Src homology 2 (SH2) domains, that mediate specific interactions with receptor autophosphorylation sites. SH2-mediated interactions are important for the activation of biochemical signalling pathways in cells stimulated with growth factors. A distinct protein module, the SH3 domain, is frequently found in polypeptides that contain SH2 domains, and is also implicated in controlling protein-protein interactions in signal transduction. Evidence suggesting that SH2 and SH3 domains act synergistically in stimulation of the Ras pathway is discussed.
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收藏
页码:279 / 285
页数:7
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