CLONING AND EXPRESSION OF A RECEPTOR FOR AN INSECTICIDAL TOXIN OF BACILLUS-THURINGIENSIS

被引：280

作者：

VADLAMUDI, RK ^{[1
]}

WEBER, E ^{[1
]}

JI, IH ^{[1
]}

JI, TH ^{[1
]}

BULLA, LA ^{[1
]}

机构：

[1] UNIV WYOMING, DEPT MOLEC BIOL, LARAMIE, WY 82071 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 10期

关键词：

D O I：

10.1074/jbc.270.10.5490

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Environmentally friendly toxins of Bacillus thuringiensis are effective in controlling agriculturally and biomedically harmful insects. However, little is known about the insect receptor molecules that bind these toxins and the mechanism of insecticidal activity. We report here for the first time the cloning and expression of a cDNA that encodes a receptor (BT-R(1)) of the tobacco hornworm Manduca sexta for an insecticidal toxin of B. thuringiensis. The receptor is a 210-kDa membrane glycoprotein that specifically binds the cryIA(b) toxin of B, thuringiensis subsp. berliner and leads to death of the hornworm. BT-R(1) shares sequence similarity with the cadherin superfamily of proteins.

引用

页码：5490 / 5494

页数：5

共 31 条

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